carvacrol timol orégano

Lett. doi:10.1111/j.1349-7006.2010.01524.x, Ingham, M., and Schwartz, G. K. (2017). Nutr. Open Chem. The review followed the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) (Page et al., 2021). ERK is generally associated with cell proliferation, while JNK and p38 are closely related to the cell death process (Wagner and Nebreda, 2009). doi:10.1016/j.ijbiomac.2018.12.095, Shojaei, S., Kiumarsi, A., Moghadam, A. R., Alizadeh, J., Marzban, H., and Ghavami, S. (2014). Uma outra via menos importantes é a oxidação dos grupos metila terminais em alcoóis primários. Carvacrol Induces Mitochondria-Mediated Apoptosis via Disruption of Calcium Homeostasis in Human Choriocarcinoma Cells. The objective of this work is to determine the. Quality of Life and Associated Factors Among Patients with Breast Cancer under Chemotherapy at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia. doi:10.1016/j.bbrc.2017.04.009, Li, Y., Xu, J. z., Gu, C. x., Liu, G. l., and Tian, K. (2018). J. Gynecol. Carvacrol Promotes Cell Cycle Arrest and Apoptosis through PI3K/AKT Signaling Pathway in MCF-7 Breast Cancer Cells. Carvacrol Timol 80%. Elshafie et al. (2020). Food Chem. Promocionado. Physiol. An update from the Infectious Diseases Society of America. There is also still a wide variation in the doses used, requiring the establishment of a consensus in respect of defining potentially effective and safe doses. 1,3,6,7 la cromatografía de gases es muy útil para realizar el análisis cualitativo y cuantitativo de todos los componentes no … Además, el Aceite Esencial de Orégano contiene naturalmente Piridoxina (Vitamina B6) y Magnesio. Received: 29 April 2021; Accepted: 22 June 2021;Published: 07 July 2021. Bras. CASPASE-8 Gene Is Inactivated by Somatic Mutations in Gastric Carcinomas. Mercado Libre Argentina - Donde comprar y vender de todo. Cel Mol Biol 34 (2), 174–181. Curr. (2014). Antiproliferative Effects of Carvacrol on Neuroblastoma Cells. IC50 values determined 24 h after the incubation of the studied cells with carvacrol or thymol were compiled, submitted to the standardization of the unit (μM) (Supplementary Table S2) and were expressed as mean ± standard error of the mean (SEM). doi:10.4103/0973-1482.154925, Siveen, K. S., Prabhu, K., Krishnankutty, R., Kuttikrishnan, S., Tsakou, M., Alali, F. Q., et al. Toxicol. doi:10.4149/neo_2014_084, Mishra, B. Tabla 1: Componentes del aceite esencial de orégano (O. vulgare) identificados por GS-MS Los quimiotipos frecuentes en esta especie son quimiotipo Carvacrol y quimiotipo Timol. The 400–600 μM range of concentrations promoted cell necrosis and the 800 μM concentration killed all cultivated cells (Hsu et al., 2011). Puede detener el crecimiento de muchas bacterias en el organismo. A sua baixa toxicidade juntamente com o aroma e sabor agradáveis, sugerem que possa ser utilizado como aditivo alimentar para prevenir a contaminação bacteriana. Cancer Res. 15 (11), 4519–4525. Mol. In particular, JNK, ERK and p38 are the main proteins of MAPK pathways when approaching cancer. Anticancer Res. Cardiovasc. When using mouse myoblast cells (CO25 cell line) transformed with human N-RAS oncogene, Zeytinoglu et al. Further studies are required to help unravel and define the mechanisms of action of the two compounds against cancer cells, as well as studies that further explore their chemopreventive and anti-metastatic effects. 22 (8), 3875–3886. 5 (1), 1–10. doi:10.1517/14728222.2014.961425, Kim, C., and Kim, B. Aplicación del método a muestras de orégano. Res. Krelin et al. 5. J. Pharm. There is, therefore, an ongoing search for substances that can be used to develop more effective treatments, with less side effects, to use against cancer; one promising group of substances are natural products (NPs). Cytotechnology 64 (1), 43–51. De La Chapa et al. Meanwhile, administration of thymol increased p21expression in bladder cancer cells (Li et al., 2017) and increased expression of both p53 and p21 in breast cancer cells (Seresht et al., 2019). Biophysical Res. doi:10.4077/CJP.2017.BAF447, Yin, Q.-h., Yan, F.-x., Zu, X.-Y., Wu, Y.-h., Wu, X.-p., Liao, M.-c., et al. doi:10.1177/1534735404270335, Dabrowska, C., Li, M., and Fan, Y. Efecto cicatrizante, analgésico, antiinflamatorio y desinfectante, gracias a compuestos como carvacrol o timol, que tienen acción bactericida y fungicida. 38 (4), 263–355. (2011). Most studies have demonstrated the effect of these compounds on carcinomas, as they are one of the most common types of cancer (Neville, 2011). en los pies. Expression and Prognostic Significance of Osteopontin and Caspase-3 in Hepatocellular Carcinoma Patients after Curative Resection. Pharmacother. Semin. J. Cel Mol Med. The History of Medicine. El orégano usado en este estudio fue cultivado en Concepción, provincia que cuenta con condiciones similares a las descritas por Téllez; por ello, los valores encontrados de timol y carvacrol son bajos. Cuantificación por Cromatografía Líquida de Alta Resolución. (2016). El lavado fue utilizando 5 min 100 % agua, flujo 1 mL/min, 5.1 min 50:50% agua acetonitrilo flujo 1 mL/min, 10 min 50:50% agua acetonitrilo, flujo 2 mL/min, 30 - 60 min 50:50% agua acetonitrilo flujo 1 mL/min, 60.1 a 90 min 50:50% agua metanol, flujo 1 mL/min. J. Physiol. introducción la determinación de timol y carvacrol en muestras de orégano y otras plantas, ha sido realizado por muchos autores utilizando métodos por hplc 1-5 y cromatografía de gases con detector fid o de masas. The proposed method uses a HPLC with a fluorescence detector, isocratic mobile phase of acetonitrile and water (ACN): H2O (50:50), a column Purospher® STAR rp-18e (4.6 x 150mm, 5mm), flow 1 ml/minute, injection volume of 20 mL and run time of 15 minutes. Siga o @medicinanaturalbrasil no Instagram. Pharmacol. (2018), after treating female athymic nude mice injected with tongue squamous cell carcinoma (Cal27 cell line) and cervical cancer (HeLa cell line), reported a significant inhibition of tumor growth and volume, besides a significant reduction in the number of proliferative cells, with thymol increasing the quantity of apoptotic cells. Se buscó las condiciones de estabilidad del sistema cromatográfico, previos a la corrida de los estándares o muestras. El grupo hidroxilo está en posición para con respecto al grupo metilo y al grupo isopropilo. 44 (2), 193–202. doi:10.1038/sj.onc.1202490, Tayarani-Najaran, Z., Akaberi, M., Hassanzadeh, B., Shirazi, N., Asili, J., Al-Najjar, H., et al. The via extracellular signal-regulated kinases (ERK) protein, and mitogen-activated protein kinases (p38) apoptotic pathways may also be involved (Yin et al., 2012). Biochem. Biometrics 33 (1), 159–174. 2011; 43 (1): 237-245. Além de combater as bactérias, alguns estudos em tubo de ensaio descobriram que o orégano e seus componentes também apresentam proteção contra alguns vírus.. Em particular, o carvacrol e o timol são dois compostos no orégano que foram associados a propriedades antivirais. Biomed. In this review, 33.3% (n = 23) of in vitro studies reported an increase of caspase activity, more specifically caspase-3 (Deb et al., 2011; Liang and Lu, 2012; Yin et al., 2012; Ferraz et al., 2013; Liang et al., 2013; Al-Fatlawi and Ahmad, 2014; Chen et al., 2015; Bhakkiyalakshmi et al., 2016; Khan et al., 2017; Li et al., 2017; Abbas and Al-Fatlawi, 2018; Chauhan et al., 2018; Günes-Bayir et al., 2018; Günes-Bayir et al., 2018; Tayarani-Najaran et al., 2019), -6 (Al-Fatlawi and Ahmad, 2014; Abbas and Al-Fatlawi, 2018), -7 (Kang et al., 2016), -8 (Deb et al., 2011; Pathania et al., 2013; Kang et al., 2016; Khan et al., 2019) and -9 (Deb et al., 2011; Pathania et al., 2013; Al-Fatlawi and Ahmad, 2014; Kang et al., 2016; Li et al., 2017; Abbas and Al-Fatlawi, 2018; Günes-Bayir et al., 2018; Günes-Bayir et al., 2018; Potočnjak et al., 2018; Khan et al., 2019). H. Franz, V. Jendreizik. In Vitro effects of Two Major Phenolic Compounds from the Family Lamiaceae Plants on the Human Gastric Carcinoma Cells. Neville, B. Para la verificación de la distribución normal de los resultados, se evaluó la linealidad a través de la relación entre la concentración del timol - carvacrol y la absorbancia por el detector de FL-HPLC. Anti-proliferative and Pro-apoptotic Activity of Carvacrol on Human Cancer Cells. ¡Descargá gratis la app de Mercado Libre! Effect of Carvacrol on Ca^(2+) Movement and Viability in PC3 Human Prostate Cancer Cells. Methods: A systematic literature search was carried out in the PubMed, Web of Science, Scopus and Lilacs databases in April 2020 (updated in March 2021) based on the PRISMA 2020 guidelines. In vitro antimicrobial activity of narasin against common clinical isolates associated with canine otitis externa. J. 27 (Suppl. Clinical Significance of Plasma MMP‐2 and MMP‐9 Levels as Biomarkers for Tumor Expression in Breast Cancer Patients in Egypt. The expression of caspase-9 was the second most reported in this review, due to its crucial role in apoptosis initiation among various types of cancer (Kim et al., 2015). Only 4.3% (n = 3) of the studies recorded reported randomness when taking photos of selected areas regarding apoptotic activity assays. Med. Crit. 8 (3), 963–971. Antimicrobiano: Carvacrol es efectivo contra patógenos transmitidos por los alimentoscomo Escherichia coli, Salmonella y Bacillus cereus. Evaluación del uso de los aceites esenciales como alternativa al uso de antibióticos promotores de crecimiento en pollos de engorde. En la figura 3 la curva de calibración del carvacrol presenta un valor de r2 de 0,999811 para concentraciones de 0,03 hasta 0,96 mg/L. Hypothese/ziele: Neoplasia can be described as a disease of unchecked cell division, and its progression is related to abnormal activity of cell cycle regulators. mirabilisの0.015〜0.03%(146〜292μg/ mL)の範囲にわたった。 緑膿菌およびM. 266, 118894. doi:10.1016/j.lfs.2020.118894, Li, S., Zhao, H., and Bao, L. (2019). J. Integr. Anticarcinogenic and Antiplatelet Effects of Carvacrol. doi:10.1016/j.ctrv.2016.03.002, Harris, S. L., and Levine, A. J. L'huile d'origan, de thym, le carvacrol et le thymol ont montré une bonne activité bactéricide et fongicide contre 100 souches de chiens avec otite externe, comprenant des souches hautement résistantes. Determinación de timol y carvacrol en una matriz orgánica de alimento . doi:10.1080/10496475.2017.1369483, Günes-Bayir, A., Kocyigit, A., Güler, E. M., Bilgin, M. G., Ergün, İ. S., and Dadak, A. Likewise, there was an increased expression of the death-associated protein kinase 1 (DAPK1) and decreased expression of serine/threonine-protein phosphatase 2A (PPP2R2A) in tumor tissues (Li et al., 2019). Molecules 26 (2), 410. doi:10.3390/molecules26020410, Carqueijeiro, I., Langley, C., Grzech, D., Koudounas, K., Papon, N., O’Connor, S. E., et al. J. Cel Biochem. 3. doi:10.1080/01913123.2020.1740366, Elbe, H., Yigitturk, G., Cavusoglu, T., Uyanikgil, Y., and Ozturk, F. (2020). Cancer Res. The Effect of Thyme Essential Oil on Liver Injuries Caused by Renal Ischemia-Reperfusion in Rats. Food Chem. doi:10.1590/S0102-695X2007000400002, Jaafari, A., Tilaoui, M., Mouse, H. A., M'bark, L. A., Aboufatima, R., Chait, A., et al. Carvacrol Induces Mitochondria-Mediated Apoptosis in HL-60 Promyelocytic and Jurkat T Lymphoma Cells. A. Phytochemicals as Potential Anticancer Drugs: Time to Ponder Nature's Bounty. Es un isómero estructural del carvacrol porque el carvacrol tiene su grupo hidroxilo en la posición para mientras que el timol tiene su grupo hidroxilo en la posición meta. Report on Cancer: Setting Priorities, Investing Wisely and Providing Care for All. Se planteó la hipótesis de que los principales componentes fenólicos tendrían una mayor actividad antimicrobiana en comparación con el aceite esencial relativo. According to the results found by Seresht et al. Nat Prod Res. Tiene fuertes propiedades antisépticas y también proporciona el sabor fuerte y distintivo de la hierba culinaria, el tomillo. Synthesis and Evaluation of Thymol-Based Synthetic Derivatives as Dual-Action Inhibitors against Different Strains of H. pylori and AGS Cell Line. World Health Organization (2020). Effects of Thymol on B16-F10 Melanoma Cells. The administration of thymol to bladder cancer (T24, SW780, J82 cell lines) provoked inhibition of cell proliferation and decreased the cell viability in a concentration and time dependent manner, along with marked cell cycle arrest in the G2/M phase and induction of apoptosis through the intrinsic pathway, together with the activation of caspase-3 and -9, JNK and p38, release of cytochrome C, negative regulation of Bcl-2 family proteins and production of ROS. J. Cel Physiol. IUBMB Life 71 (2), 166–176. The Cytotoxic Effects of Thymol as the Major Component of Trachyspermum Ammi on Breast Cancer (MCF-7) Cells. In vitro antimicrobial effect of essential tea tree oil(. Elimina Cándida. 46 (8), 497–510. Aceite de oregano que . TABLE 1. 8 (2), 105–116. doi:10.1126/science.290.5493.989, Keywords: carvacrol, thymol, cancer, antitumor, anticancer, Citation: Sampaio LA, Pina LTS, Serafini MR, Tavares DdS and Guimarães AG (2021) Antitumor Effects of Carvacrol and Thymol: A Systematic Review. doi:10.1371/journal.pone.0135078, PubMed Abstract | CrossRef Full Text | Google Scholar, Ahmed, H., Shousha, W., El-Mezayen, H., Ismaiel, N., and Mahmoud, N. (2013). doi:10.1016/j.canlet.2016.03.042, Riaz, S. K., Iqbal, Y., and Malik, M. F. A. doi:10.1155/2020/8602879, Asif, M. (2015). C. Amadio, M. E. Zimmermann, R. Medina, S. Miralles, C. Dediol. Cancer Prev. Management from Around the World. longevity 2016, 1404505. doi:10.1155/2016/1404505, Collins, T. S., and Hurwitz, H. I. Similarly, Subramaniyan et al. Regulation of C6 Glioma Cell Migration by Thymol. doi:10.1177/1934578x1200701201, Page, M. J., McKenzie, J. E., Bossuyt, P. M., Boutron, I., Hoffmann, T. C., Mulrow, C. D., et al. (2004) identificaram proporção muito superior de timol do que carvacrol em O. vulgare L. (orégano) cultivado na região sul do Rio Grande do Sul. doi:10.1016/j.cbi.2011.05.009, Elbe, H., Yigitturk, G., Cavusoglu, T., Baygar, T., Ozgul Onal, M., and Ozturk, F. (2020). In this review, caspase-6 and -7 expression was reported in only three studies. Gaia Herbs Oil of Oregano - Immune and Antioxidant Support Supplement to Help Sustain Overall Well-Being - with Oregano Oil, Carvacrol, and Thymol - 60 Vegan Liquid Phyto-Capsules (30-Day Supply) 60 Count (Pack of 1) 4.7 (8,109) $2239 ($0.37/Count) $20.15 with Subscribe & Save discount. (2016). In vivo, Suntres et al. For P. aeruginosa and M. pachydermatis, MIC90 values ranged from 0.09 to 0.25% (800-2,292 μg/mL). Role of BAX in the Apoptotic Response to Anticancer Agents. In addition, the TRPM7 pathway is one of the suggested pharmacological mechanisms of action (Li et al., 2021). In this review, it was noted that three in vitro studies (4.4%) reported that carvacrol decreased CDK4 protein expression in human tongue squamous cell carcinoma (Tca-8113 cells) (Dai et al., 2016) and in breast cancer (MCF-7 cells) (Mari et al., 2020; Li et al., 2021) and only one (1.4%) reported a decrease in CDK6 in MCF-7 cells (Mari et al., 2020). (2018). Conception and design: AG, DT, and LS. Carvacrol and Rosemary Essential Oil Manifest Cytotoxic, DNA-Protective and Pro-apoptotic Effect Having No Effect on DNA Repair. Cytotoxic Activity of Origanum Vulgare L. On Hepatocellular Carcinoma Cell Line HepG2 and Evaluation of its Biological Activity. FIGURE 3. Together with VEGF, other enzymes collaborate for neoplastic invasion, such as mitochondrial membrane potential. doi:10.1158/0008-5472.CAN-18-2738, Soung, Y. H., Lee, J. W., Kim, S. Y., Jang, J., Park, Y. G., Park, W. S., et al. Cytotoxicity and Morphological Effects Induced by Carvacrol and Thymol on the Human Cell Line Caco-2. 背景: 多重耐药菌的抗菌治疗是一项全球均需面临的重要挑战,并且其经常使犬外耳炎复杂化。 假设/目的: 研究牛至油、百里香油及其主要酚类成分,对细菌和真菌引起的犬外耳炎的体外疗效。与精油相比,推测主要酚类成分具有更高的抗菌活性。 方法和材料: 使用肉汤微量稀释和点镀技术进行药敏试验,以确定最小抑菌、杀菌和杀真菌浓度(MIC、MBC和MFCs)。采用时间-杀菌动力试验以确定精油及其酚类成分的杀菌和杀真菌活性。共选取从犬外耳炎中分离的100株细菌和真菌菌株,包括甲氧西林敏感(n = 10)和甲氧西林耐药(n = 10)的假中间型葡萄球菌、β-溶血性链球菌(n = 20)、铜绿假单胞菌(n = 20;包括对一种或两种抗生素耐药的10个菌株)、奇异变形杆菌(n = 20)和厚皮马拉色菌(p = 20)。 结果: 牛至油、百里香油、香芹酚和百里香酚对所有检测的细菌和真菌菌株均有抗菌活性。对于革兰氏阳性菌和奇异变形杆菌,MIC90 值范围为0.015-0.03%(146-292μg/ mL);对于铜绿假单胞菌和厚皮马拉色菌,MIC90 的数值范围为0.09-0.25%(800-2292μg/ mL)。 结论和临床意义: 牛至油、百里香油、香芹酚和百里香酚对100株犬外耳炎菌株(其中还包括一些高度耐药的菌株),均有良好的体外杀菌和杀真菌活性。精油及其主要酚类成分治疗犬外耳炎的效果,需要进行更多的体内试验来获得。. Ingresa a tu cuenta para ver tus compras, favoritos, etc. In addition, some inhibitors of this signaling pathway have already been approved by the Food and Drug Administration for cancer treatment (Alzahrani, 2019). doi:10.1016/s0959-8049(00)00297-5, Krelin, Y., Zhang, L., Kang, T.-B., Appel, E., Kovalenko, A., and Wallach, D. (2008). Es un fenol monoterpenoide. Cuando lo utilizamos de forma externa, ya sea mediante infusión de orégano o mediante alcohol o aceite de orégano, tendremos los siguientes beneficios. doc.documentElement.appendChild(s); Clin. (2014) also evaluated the effect of carvacrol pre- and post-treatment on a DEN-induced hepatocarcinogenesis rat model and observed a stability in tumor marker levels, a reduced mast cell density and inhibition of cell proliferation. The Mechanism of Carvacrol-Evoked [Ca2+]i Rises and Non-ca2+-triggered Cell Death in OC2 Human Oral Cancer Cells. 18 (1), 108–118. Both are monoterpenoid phenols, the main components present in essential oils obtained from several plant species of the Lamiaceae and Verbenaceae families, such as oregano (Origanum vulgare L.), thyme (Thymus vulgaris L.) and “alecrim-da-chapada” (Lippia gracilis) (Santos et al., 2016; Salehi et al., 2018; Sharifi-Rad et al., 2018; Baj et al., 2020), which have already been reported to exhibit beneficial effects against many diseases (Silva et al., 2018), including cancer (Elbe et al., 2020; Pakdemirli et al., 2020). En el presente trabajo se validó el método de determinación por HPLC con detector de Fluoresencia de timol y carvacrol en muestras de Origanum vulgare, bajo las condiciones mencionadas en el artículo, utilizando la linealidad, límites de detección y cuantificación, selectividad, precisión, recuperación 1,9,10. Dis. Plants 24 (1), 37–51. Carvacrol Alters Soluble Factors in HCT-116 and HT-29 Cell Lines. Molecules 25 (14), 3270. doi:10.3390/molecules25143270, Günes-Bayir, A., Kocyigit, A., and Güler, E. M. (2018). The antiproliferative activity of carvacrol was 1.2 times higher against MDA-MB231 cells compared to U87 cells (Baranauskaite et al., 2017). There was also inhibition of HCT116, LoVo and HT-29 cells proliferation (Fan et al., 2015; Pakdemirli et al., 2020). Aparte de eso, también puede disolverse en soluciones alcalinas fuertes debido a su capacidad para desprotonar. Value of the Serum Alpha-L-Fucosidase Activity in the Diagnosis of Colorectal Cancer. Moreover, genotoxic effects have been shown to be exhibited by carvacrol (Günes-Bayir et al., 2018) and thymol (Günes-Bayir et al., 2018), and it was also shown that a high concentration of carvacrol (460 µM) exhibited mutagenic and genotoxic effects causing DNA damage (Llana-Ruiz-Cabello et al., 2015). Toxicol. Drug Resist. Para P. aeruginosa y M. pachydermatis, los valores de MIC90 variaron de 0,09 a 0,25% (800-2,292 μg/mL). MÉTODOS E MATERIAIS: Realizou-se teste de suscetibilidade a antimicrobianos utilizando a microdiluição em caldo com técnica de plaqueamento pontual para determinar a concentração inibitória mínima e as concentrações bactericidas/fungicidas (MICs, MBCs e MFCs). [12], Em ratos, o carvacrol é rapidamente metabolizado e excretado. The Roles of ROS in Cancer Heterogeneity and Therapy. 15 (1), 11–18. El equipo de HPLC utilizado es Hitachi Elite LaChromm, con el Software EZChrom Elite v3.3.2, equipado con bomba L-2130, válvula gradiente baja presión L-2130ACC, degasificadora L-2000ACC, Interface USB IFU, horno de columnas L-2350, Inyector manual 7725i-006, mezclador cuaternario de solventes; el detector utilizado fue el Hitachi FL Detector L-2485; se utilizó la longitud de onda de excitación: 230 nm, longitud de onda de emisión: 280 nm. Study of Cytotoxic, Genotoxic and DNA-Protective Effects of Selected Plant Essential Oils on Human Cells Cultured In Vitro. The research was carried out in the databases PubMed, Web of Science, Scopus and Lilacs in April 2020 (updated in March 2021) using a combination of health descriptors, MeSH terms and their synonyms, such as antitumor, antineoplastic, anticancer, cytotoxicity, apoptosis, cell proliferation, in vitro, in vivo, carvacrol or 5-isopropyl-2-methylphenol and thymol or 5-methyl-2-propan-2-ylphenol (Supplementary Table S1, contains a complete list of these search terms). Epub 2019 Nov 15. (2016). Effect of Thymol on Ca^(2+) Homeostasis and Viability in PC3 Human Prostate Cancer Cells. Determinación de timol y carvacrol en hojas de orégano por HPLC FL, Determination of thymol and carvacrol on oregano leaves via HPLC FL, Lena Téllez1; Fermín Arévalo1; Henry Juárez2; Pedro Altamirano1; Karina Ccapa1; Jorge Chávez3; Lizardo Visitación1, 1 Centro de Investigación en Química, Toxicología y Biotecnología Ambiental del Departamento Académico de Química de la Facultad de Ciencias de la UNALM Lima – Perú. (2010). Al navegar en nuestro sitio aceptas que usemos cookies para personalizar tu experiencia según la Declaración de Privacidad. (2015). Koyama, H., Iwata, H., Kuwabara, Y., Iwase, H., Kobayashi, S., and Fujii, Y. Cancer Prev. Oreganoöl, Thymianöl, Carvacrol und Thymol zeigten eine gute in vitro bakterizide und fungizide Aktivität gegenüber 100 Isolaten von Hunden mit Otitis externa, wobei einige hochresistente Isolate dabei waren. doi:10.5772/50277, Song, H.-Y., Deng, X.-H., Yuan, G.-Y., Hou, X.-F., Zhu, Z.-D., Zhou, L., et al. Desta forma, o carvacrol pode ser uma opção para o tratamento complementar de doenças como a gastroenterite (infecção que atinge o sistema gastrointestinal podendo haver a ocorrências de diarreias, cólicas intestinais e possivelmente vômitos), colecistite (inflamação da vesícula biliar), toxemia (presença de bactérias no sangue), colangite (inflamação das vias biliares), infecção do trato urinário, além de vários outros tipos de infecções comuns, como meningite e pneumonia neonatal. Treatment with carvacrol in leiomyosarcoma cells exhibited antiproliferative effects in a concentration dependent manner and also inhibition of cell growth (Karkabounas et al., 2006). (2018). É relacionado ao carvacrol, possuindo a mesma fórmula molecular, porém os átomos estão dispostos de forma diferente. In addition, carvacrol showed a greater cytotoxicity compared to thymol against murine mast cell cells (P-815 cell line) (Jaafari et al., 2007; Jaafari et al., 2012), with accumulation of cells in the S phase (Jaafari et al., 2012). El timol pertenece al grupo de los terpenos. 2022 Oct;15(10):2499-2505. doi: 10.14202/vetworld.2022.2499-2505. Toxicol. El carvacrol y el timol son compuestos orgánicos cíclicos que contienen un grupo metilo, un grupo hidroxilo y un grupo isopropilo. A time-kill kinetics assay was performed to confirm the bactericidal and fungicidal activity of the oils and their phenolic constituents. Oncol. Thus, the dose-response relationship must be considered in more detail, so that further studies in more advanced stages are developed to assess the antitumor effects of these compounds. Res. Our review identified a considerable number of reports (77 studies) published in the last two decades, with an increasing trend over recent years. Al considerar las propiedades físicas de este compuesto, tiene el característico olor acre y cálido del orégano. Final approval of the completed manuscript: AG and DT. Palabras clave: Orégano, timol, carvacrol, aceites esenciales, HPLC. An adapted protocol of the SYRCLE Risk of Bias tool was used to evaluate the methodological quality of in vitro studies, as described by Chan et al. (2020). Cell cycle arrest was observed in the G0/G1 phase, with decreased Bcl-2 protein levels and interruption of mitochondrial homeostasis; increased ROS production, mitochondrial production of H2O2, and Bax protein levels; and activation of caspase-8, -9, -3 and PARP (Deb et al., 2011). C.C. doi:10.1016/j.ejmech.2011.07.057, Nagase, H., Visse, R., and Murphy, G. (2006). We used the Kappa statistical test to measure the inter-rater reliability (Landis and Koch, 1977). Eur. 23 (4), 310–319. Toxicol. Pharm. (2012). También podemos producir carvacrol sintéticamente mediante la fusión de ácido cymol sulfónico en presencia de potasa cáustica. Se ha determinado un valor de resolución Rs de 1,65, lo que indica una buena resolución de los picos de timol y carvacrol. Sci. Med. At 200 μM, the MDA-MB-231 cell line was the most sensitive and MCF-7 was the least sensitive, indicating that the effectiveness of carvacrol may vary according to the types of breast cancer cell. Mol. Effects of Carvacrol on a Human Non-small Cell Lung Cancer (NSCLC) Cell Line, A549. In vitro, methotrexate and vincristine (0.5 µg/100 µL) (Jaafari et al., 2007), 5-fluorouracil (5-FU) (2.6 μg/μM) (Maryam et al., 2015), doxorubicin (0.5, 5, 10, and 20 μg/mL) (Tayarani-Najaran et al., 2019) (1.0 μg/mL) (Ferraz et al., 2013) and (2 μM) (Kang et al., 2016), camptothecin (5 μM) (Deb et al., 2011) and in vivo, doxorubicin (2 mg/kg) (Zeng et al., 2020), were the main substances used to compare the potential therapeutic effect of these monoterpenes. The Staphylococcus aureus bacterium is one of the most . 395 (1), 65–76. National Library of Medicine. doi:10.1007/s12094-007-0138-9, Gottlieb, T. M., and Oren, M. (1998). Varios estudios han probado la capacidad del aceite de orégano para aliviar el dolor de golpes, esguinces, tendinitis y artritis. 48000 pesos $ 48.000. Oregano (Origanum vulgare L.) is an aromatic native plant originated from the Mediterranean region and it's traditionally grown in the south of Peru. (2014). TABLE 2. Antibiotics (Basel). 2 (6), a001198. Aceite esencial de orégano: un potencial aditivo alimentario. É um óleo espesso que assenta a 20 °C numa massa de cristais com ponto de fusão 0 °C, e ponto de ebulição 236–237 °C. The https:// ensures that you are connecting to the Furthermore, supplementation with carvacrol significantly restored the activities of liver microsomal xenobiotic metabolizing enzymes to normal, with a reduced expression of proliferative nuclear cell antigen (PCNA), MMP-2 and -9, and thereby prevented the local spread of carcinogenic cells, showing an antimetastatic effect (Subramaniyan et al., 2014). Cell Death Differ. It is of note that several studies suggested that signaling pathways (PI3K/AKT/mTOR and MAPKs) may be the main mechanism of action of these monoterpenoids, but more advanced studies are needed to elucidate this issue. 22 (5), 41–53. World Health Organization; Report on Cancer: Setting Priorities, Investing Wisely and Providing Care for All. 59, 125–132. Biol. Int. Además de la extracción de sus fuentes naturales, podemos sintetizar timol químicamente a través de la reacción entre m-cresol y propeno. Diese essentiellen Öle und ihre hauptsächlichen phenolischen Bestandteile haben das Potential in vivo für die Therapie einer Otitis externa des Hundes weiter untersucht zu werden. Origanum majorana e Origanum dictamnus são ricas em carvacol, 50% e 60-80% respectivamente. Expert Opin. León-Rodríguez, A. de, Escalante-Minakata, P., Jiménez-García, M. I., Ordoñez-Acevedo, L. G., Flores Flores, J. L. and Barba de la Rosa, A. P., Food Technology and Biotechnology, 2008, Volume 46, Number 4, pages 448-455 (, parte superior da página, em frente ao título do artigo, condições normais de temperatura e pressão, Referências e avisos gerais sobre esta caixa, «Carvacrol data sheet from Sigma-Aldrich», http://www.liu.edu/Brooklyn/About/News/Press-Releases/2012/April/BK-PR-Apr25-2012.aspx, http://www.hort.purdue.edu/newcrop/proceedings1993../V2-628.html, http://www.herbapolonica.pl/magazines-files/2733672-art.3.pdf, Journal of Radioanalytical and Nuclear Chemistry, https://pt.wikipedia.org/w/index.php?title=Carvacrol&oldid=57189741, !Artigos que necessitam de esclarecimento, !Artigos que incorporam texto da Encyclopædia Britannica, Atribuição-CompartilhaIgual 3.0 Não Adaptada (CC BY-SA 3.0) da Creative Commons, 25 bactérias e estirpes periodontopáticas diferentes, Este artigo incorpora texto (em inglês) da. The original contributions presented in the study are included in the article/Supplementary Material, further inquiries can be directed to the corresponding author. Un sinónimo de este compuesto es cymophenol. Ultrastructural Pathol. doi:10.1016/j.bmcl.2018.06.044, Marullo, R., Werner, E., Degtyareva, N., Moore, B., Altavilla, G., Ramalingam, S. S., et al. Se colectó hojas de Origanum vulgare provenientes de zonas de cultivo en Tacna, Perú. Se obtuvo el cromatograma de la figura 4, donde la concentración de carvacrol fue de 0,003 mg/L y la de timol fue de 0,189 mg/L. doi:10.1002/jcb.28098, Liang, W.-Z., Chou, C.-T., Lu, T., Chi, C.-C., Tseng, L.-L., Pan, C.-C., et al. α-Terpineol Reduces Cancer Pain via Modulation of Oxidative Stress and Inhibition of iNOS. Carvacrol is a compound found in various herbs including oregano and oregano essential oil. Bellow this altitude, the concentration of essential oils (thymol and carvacrol) decreases. Thymol also promoted cytotoxicity and apoptosis of KLN 205 cells with an IC50 of 421 and 229.68 μM in 48 and 72 h, respectively (Elbe et al., 2020). doi:10.4149/BLL_2020_016, Elshafie, H., Armentano, M., Carmosino, M., Bufo, S., De Feo, V., and Camele, I. PI3K/Akt/mTOR Inhibitors in Cancer: At the Bench and Bedside. (2015). Otolaryngol. Boucher HW, Talbot GH, Bradley JS et al. Toxicol. Es wurde die Hypothese aufgestellt, dass die hauptsächlichen Phenol-Komponenten eine größere antimikrobielle Aktivität im Vergleich zu den relativen essentiellen Ölen haben. 1. Synthesis and Biological Evaluation of Carvacrol-Based Derivatives as Dual Inhibitors of H. pylori Strains and AGS Cell Proliferation. Access to Medicines through Health Systems in Low- and Middle-Income Countries. 12:702487. doi: 10.3389/fphar.2021.702487. Molecules 26 (7), 1829. doi:10.3390/molecules26071829, Sisto, F., Carradori, S., Guglielmi, P., Traversi, C. B., Spano, M., Sobolev, A. P., et al. Methodol. El carvacrol es un compuesto orgánico que tiene la fórmula química C10H14O. doi:10.4014/jmb.1506.06073, Karkabounas, S., Kostoula, O. K., Daskalou, T., Veltsistas, P., Karamouzis, M., Zelovitis, I., et al. eCollection 2022. However, the toxicity and side effects of many treatments can worsen the quality of life of these individuals (Weingart et al., 2018; Hassen et al., 2019; Lu et al., 2019). Additionally, there was an increase in the production of ROS and cell death (Chang et al., 2011). Chem. 19 (13), 1588–1608. Sci. Podemos encontrar carvacrol de forma natural en los aceites esenciales de orégano, tomillo, pepperwort y bergamota silvestre. Background: It is estimated that one in five people worldwide faces a diagnosis of a malignant neoplasm during their lifetime. Commun. O carvacrol pode ser sintetizado pela fusão de cimol-ácido sulfónico com potassa cáustica; pela acção do ácido nitroso sobre 1-metil-2-amino-4-propil benzeno; pelo aquecimento prolongado de cinco partes de cânfora com uma parte de iodo; ou aquecendo carvol com ácido fosfórico glacial ou ainda por meio de desidrogenação de carvona com um catalisador Pd/C. The Essential Oil of Cymbopogon Citratus Stapt and Carvacrol: An Approach of the Antitumor Effect on 7,12-Dimethylbenz-[α]-Anthracene (DMBA)-Induced Breast Cancer in Female Rats. to provide guidance for future research. doi:10.2174/1381612824666181003123400, Sisto, F., Carradori, S., Guglielmi, P., Spano, M., Secci, D., Granese, A., et al. outline: none; Pharmacognosy Magazine; 2010; 6 (23): 154-158. Moreover, India and China have, historically, made important contributions to knowledge about medicinal plants, being responsible for some of the most ancient reports about this issue, that were written approximately 5,000 and 4,000 years ago, respectively (Wiart, 2007; Kelly, 2009). Ademá, lo cuervo viven en grupo, mientr... Reservados Todos Los Derechos © es.strephonsays.com - 2023 Asian Pac. Thymol also promoted a marked antitumor effect on cervical cancer (HeLa cell line), through cytotoxic effects on the concentration of 30.5 ng/mL (Abed, 2011). doi:10.1080/01480545.2018.1538233, Giardina, M. G., Matarazzo, M., Varriale, A., Morante, R., Napoli, A., and Martino, R. (1992). In addition, the level of phosphorylated ERK decreased in hepatocarcinoma, colon cancer, choriocarcinoma and prostate cancer cells, after treatment with carvacrol, and p-ERK1/2 levels decreased after thymol treatment in glioma cells (Yin et al., 2012; Fan et al., 2015; Heidarian and Keloushadi, 2019; Lim et al., 2019). doi:10.1038/cdd.2014.216, Sharifi-Rad, M., Varoni, E. M., Iriti, M., Martorell, M., Setzer, W. N., Del Mar Contreras, M., et al. (2000). doi:10.1146/annurev.physiol.60.1.619, Landis, J. R., and Koch, G. G. (1977). Saputra S, Jordan D, Worthing KA et al. Para la extracción del aceite se ha utilizado la variedad Origanum minutiflorum, la cual no puede ser . Carvacrol is present in the essential oil of Origanum vulgare (oregano), oil of thyme, oil obtained from pepperwort, and wild bergamot. Macromolecules 125, 1069–1074. These effects seem to be related to the oxidative damage observed after the increase of ROS levels (Satooka and Kubo, 2012). A Comparative Evaluation of Antioxidant and Anticancer Activity of Essential Oil from Origanum Onites (Lamiaceae) and its Two Major Phenolic Components. (2015) reported that high caspase-3 expression caused apoptosis of tumor cells, and is significantly associated with better prognosis in patients with non-small cell lung cancer (Yoo et al., 2004) and hepatocellular carcinomas (Huang et al., 2010). Similarly, Heidarian and Keloushadi (2019) reported that this monoterpene acts through the negative regulation of pERK1/2, pSTAT3 and pAKT expression, suggesting that inhibition of interleukin-6 (IL-6) signaling pathways can be a promising target for prostate cancer treatment. Cancer Prev. Background: doi:10.1007/s10616-013-9547-5, Ayude, D., Fernández-Rodríguez, J., Rodríguez-Berrocal, F. J., Martínez-Zorzano, V. S., De Carlos, A., Gil, E., et al. Curr. Available at: http://www.who.int/publications/10-year-review/en/ (Acesseced November 20, 2020). 60, 619–642. J. Pharmacol. Regulatory Roles of MAPK Phosphatases in Cancer. Trends Mol. doi:10.2174/1389557519666190311155021, Thakor, P., Subramanian, R. B., Thakkar, S. S., Ray, A., and Thakkar, V. R. (2017). Carvacrol; Dağ kekiğinin uçucu bileşenleri timol ve carvacrol olarak ayrılıp aktif oksijenle timolun etkinliği doyuma ulaştırılıp Carvacrol'un (C10 H14 O) frekans ve emilimini yükselterek, aktifleyip biyoaktif bir solüsyon haline getiriyoruz. In summary, we observed that more in vivo studies, particularly in respect of thymol, are needed. 4. Lab. Food Chem. (2012) revealed that the latter was more sensitive to thymol effects, resulting in the accumulation of cells in the G0/G1 phase. (2018). Comparative Study of DNA-Damaging and DNA-Protective Effects of Selected Components of Essential Plant Oils in Human Leukemic Cells K562. Es wurden einhundert bakterielle und mykologische Isolate, inklusive Methicillin-empfindlichem Staphylococcus pseudintermedius (n = 10), Methicillin-resistentem S. pseudintermedius (n = 10), β-hämolytischem Streptococcus spp. doi:10.1049/iet-nbt.2014.0040, Mehdi, S., Ahmad, A., Irshad, M., Manzoor, N., and Rizvi, M. (2011). doi:10.1023/b:cyto.0000039917.60348.45. Inhibition of TRPM7 by Carvacrol Suppresses Glioblastoma Cell Proliferation, Migration and Invasion. doi:10.1002/1097-0142(19920901)70:5<1044::aid-cncr2820700506>3.0.co;2-u, Gordaliza, M. (2007). A., et al. Reprod. However, this effect is very limited compared to the natural oregano oil. The decrease in serum levels of these biomarkers in animals treated with carvacrol may prove to be an important antitumor characteristic that deserves attention and further studies to elucidate this mechanism (Ahmed et al., 2013). Cancer Biol. doi:10.1371/journal.pone.0222629, Heidarian, E., and Keloushadi, M. (2019). O óleo de orégano pode causar reações alérgicas em algumas pessoas. Aceite Oleato Orégano. The generation of ROS inside the cell contributes to the antitumor process in order to induce DNA damage and slow the progression of the cell cycle, preventing cells with DNA damage (cancer cells) from continuing with cell division (Allawzi et al., 2019; Srinivas et al., 2019). Toxicol. Integr. Carvacrol is a compound of many aromatic plants that are usually used as spices in culinary and for therapy/prevention purposes in folk medicine. JNK Signaling in Cancer Cell Survival. La precisión del método indica el grado de dispersión entre la determinación de la misma muestra. outline: none; Protective Effect of Geraniol Inhibits Inflammatory Response, Oxidative Stress and Apoptosis in Traumatic Injury of the Spinal Cord through Modulation of NF-Κb and P38 MAPK. Nat. Prepara un aceite de orégano o diluye el aceite esencial de romero en aceite base (de almendras dulces . El carvacrol y el timol son compuestos orgánicos cíclicos. Todos os direitos reservados. (2018). [7] Em Pseudomonas aeruginosa causa danos à membrana celular e, ao contrário de outros terpenos, inibe a sua proliferação. Can. Como se muestra en la imagen de arriba, la estructura química del carvacrol contiene un grupo metilo. Here are 9 potential benefits and uses of oregano oil. Available at: https://www.who.int/publications/i/item/who-report-on-cancer-setting-priorities-investing-wisely-and-providing-care-for-all (Acesseced November 13, 2020). El timol y el carvacrol, dos compuestos activos que se encuentran dentro de los beneficios del orégano, aumentan la potencia de la digestión, también es conocido por sus actividades antibacterianas y antisépticas, de igual forma, pueden aliviar la fiebre, la gripe y el dolor abdominal de inmediato. El producto OréganoAceite de SURA VITASAN destaca por ser el que presenta la mayor concentración natural de carvacrol (91_95%) en comparación con otros aceites de orégano disponibles en el mercado. One hundred bacterial and fungal isolates, including meticillin-susceptible Staphylococcus pseudintermedius (n = 10), meticillin-resistant S. pseudintermedius (n = 10), β-haemolytic Streptococcus spp. Tanto el aceite de orégano como el de tomillo son muy ricos en timol y carvacrol, y los investigadores de la Universidad de Gante sostienen que es capaz de antagonizar la colonización por bacterias del tipo Shigella spp. PLoS ONE 14 (9), e0222629. É extraída do óleo de Origanum usando uma solução de potassa a 50%. ACEITE DE ORÉGANO 150 MG: Nuestro Aceite de Orégano contiene Carvacrol, Timol y otros Terpenos, antisépticos y antioxidantes naturales, que promueven la Salud Digestiva y Respiratoria. (2019). Cell Res. Rev. Neuro Endocrinol. In addition, carvacrol showed a reduction in serum levels of alpha-fetoprotein (AFP), alpha l-fucosidase (AFU), vascular endothelial growth factor (VEGF) and decreased expression of the gamma glutamyl transferase (GGT) gene (Ahmed et al., 2013). Os terpenos possuem propriedades antibacterianas e o ácido rosmarínico possui atividades antioxidante, anti-inflamatória e antimicrobiana. Through in vitro studies, we found that carvacrol proves to be more potent than thymol, and appears to have a greater cytotoxic effect for some cell lines, such as carcinomas (prostate and stomach) (Khan et al., 2017; Günes-Bayir et al., 2018; Khan et al., 2019). (2016). Additionally, 26% (n = 18) of in vitro studies reported negative regulation of the anti-apoptotic protein Bcl-2 (Swanton et al., 1999; Kroemer et al., 1998). Chin. Biol. Cytotoxicity and Pro-apoptotic Activity of Carvacrol on Human Breast Cancer Cell Line MCF-7. O carvacrol não apresenta muitos riscos genotóxicos a longo prazo. Cell Longevity 2016, 1–11. Effect of Thymol on Ca2+ Homeostasis and Viability in MG63 Human Osteosarcoma Cells. Thymol Elicits HCT-116 Colorectal Carcinoma Cell Death through Induction of Oxidative Stress. (2021). Pathol. The Comparative Clinical Pharmacology and Pharmacokinetics of Vindesine, Vincristine, and Vinblastine in Human Patients with Cancer. Os benefícios medicinais do óleo essencial de orégano foram utilizados para tratar doenças pulmonares, bronquite, sinusite e tosses. DAPK1 is a serine/threonine kinase, a tumor suppressor protein that promotes apoptosis (Agodi et al., 2015; Zhai et al., 2019), while PPP2R2A, a regulatory subunit of protein phosphatase 2A (PP2A), controls the pathway of AKT signaling associated with tumor growth (Wang et al., 2016; Zeng et al., 2016). (2015) reported cytotoxic effects of carvacrol on gastric cancer (AGS cell line) significantly reducing cell viability in a manner dependent on concentration. Liver Dis. (2018) demonstrated that the cytotoxicity exhibited by carvacrol against HeLa cells occurred through the suppression of the cell cycle and induction of apoptosis, the latter accompanied by an increase in caspase-9, PARP cleavage, and activation of ERK, increasing the expression of phospho-ERK1/2. Excessive activation of mTOR (mammalian target of rapamycin), a serine/threonine kinase, is associated with the activation of hypoxia inducible factor (HIF) that regulates angiogenesis and tumor growth (Semenza, 2003). Carvacrol Exhibits Anti-oxidant and Anti-inflammatory Effects against 1, 2-dimethyl Hydrazine Plus Dextran Sodium Sulfate Induced Inflammation Associated Carcinogenicity in the colon of Fischer 344 Rats. El proyecto fue financiado por el Fondo de Innovación en Ciencia y Tecnología – FINCyT, Fondo de Investigación y Desarrollo Para la Competitividad (FIDECOM) con el Contrato PCyT – FIDECOM – Molinos Cusco – Convenio N°049-2012. Mol. Serum Alpha-L-Fucosidase. 11 (4), 2619–2624. Pharmacol. There was almost perfect (Landis and Koch, 1977) reliability/agreement (κ = 0.813) among the reviewers, after selecting the titles and abstracts. Los diferentes métodos de determinación hacen uso de diferentes tipos de columnas de marcas registradas y diversas longitudes, pero todas tienen en común el uso de una columna de fase reversa C-18. J. Clin. doi:10.1016/j.semcancer.2017.04.015, Olsson, M., and Zhivotovsky, B. Cytotoxic, Cytogenetics and Immunomodulatory Effects of Thymol from Thymus Vulgaris on Cancer and Normal Cell Lines In Vitro and In Vivo. 60 (5), 275–283. Resumen. 92, 491–500. *:focus-visible { O uso é contraindicado durante a gravidez. En uso interno Antibacteriano. A significant reduction in cancer growth, a greater number of necrotic lesions and a lower level of Ki-67 expression were observed, which reflects cell proliferation. 55 (3), 304–318. Based on these data, we compiled the IC50 (μM) values determined 24 h after the incubation of the studied cells with carvacrol or thymol. (2018). HHS Vulnerability Disclosure, Help It is noteworthy that the positive regulation of caspase-3 propagates and amplifies the apoptosis signal, and its loss of expression promotes tumorigenesis (Fiandalo and Kyprianou, 2012). 16 (5), 1677–1682. Forty-three used carvacrol, 19 thymol, and 15 studies tested both monoterpenes. (1990). Effects of Carvacrol on Human Fibroblast (WS-1) and Gastric Adenocarcinoma (AGS) Cells In Vitro and on Wistar Rats In Vivo. Of these, 388 were excluded due to duplication. Rep. 73 (1), 240–254. Rev. (2017). PubChem . Thymol and Carvacrol also have antibacterial properties as pure substances. doi:10.3109/14756366.2016.1161620, Jamali, T., Kavoosi, G., Safavi, M., and Ardestani, S. (2018). doi:10.4077/cjp.2017.bag506. Carvacrol Affects Breast Cancer Cells through TRPM7 Mediated Cell Cycle Regulation. Cel Biochem. [8] Pensa-se que as suas propriedades anitmicrobianas se devam ao facto de produzir disrupção da membrana bacteriana. [11], Activa a inflamação por PPAR suprime a inflamação por COX-2. La investigación se realizó en los Laboratorio del Departamento de Química de la Facultad de Ciencias de la UNALM, Laboratorio de Instrumentación del Instituto de Investigación en Bioquímica y Biología Molecular y los campos experimentales de cultivo de Molinos,Cusco S.A. Historicamente, os médicos gregos usavam óleo de orégano no tratamento de dores de cabeça, feridas, picadas venenosas e até mesmo para desintoxicação de envenenamento causado por cicuta. Se tomó 1000 g de material fresco de hojas de O. vulgare. Cancer Med. Pathol. Chemotherapy Medication Errors. (2017). Al-mustansiriyah J. Sci. Horvathova, E., Turcaniova, V., and Slamenova, D. (2007). Oxidative Med. Estes óleos essenciais e seus constituintes fenólicos possuem potencial no tratamento da otite externa canina e devem ser investigados in vivo. Epub 2019 May 21. doi:10.21873/anticanres.11159, Fouad, H., Salem, H., Ellakwa, D. E. S., and Abdel‐Hamid, M. (2019). Su principio activo, el carvacrol y el timol, son importantes antioxidantes y pueden ayudar a reforzar la función inmune. O orégano possui alta atividade antioxidante pela presença de ácido fenólico e flavonoides, além de propriedades antimicrobianas contra a bactéria Listeria monocytogenes e outros patógenos presentes nos alimentos, o . More recently, other compounds, such as perillyl alcohol and limonene -monoterpenes found in aromatic plant species, have been widely studied due to their antitumor potential, and have been included in clinical phase studies (Shojaei et al., 2014; Arya and Saldanha, 2019). La importancia de esta planta se refleja en el alto valor agregado que adquiere su aceite esencial por sus componentes químicos, como el Timol (67,51%). The induction of PC-3 cells apoptosis was mostly through the intrinsic pathway, associated with the production of ROS and mediated by the increase expression of caspase-3, -8 and -9 and Bcl-2/Bax. doi:10.1016/j.phymed.2009.12.008, Arya, R., and Saldanha, S. N. (2019). Functions of the MAPK Family in Vertebrate-Development. [24], Nesta Wikipédia, os atalhos de idioma estão na, 1/C10H14O/c1-7(2)9-5-4-8(3)10(11)6-9/h4-7,11H,1-3H3, Characterization of volatile compounds from ethnic Agave alcoholic beverages by gas chromatography-mass spectrometry. Oregano Öl Anwendung 181 (6), 1895–1899. Osguthorpe JD, Nielsen DR. Otitis externa: review and clinical update. (2017). Pharmacological Effects of Carvacrol in In Vitro Studies: A Review. pachydermatisの場合、MIC90 値は0.09〜0.25%(800〜2,292μg/ mL)の範囲に及んだ。 結論と臨床的重要性: オレガノ油、タイム油、カルバクロールおよびチモールは、外耳炎を有する犬から採材された100の分離株(いくつかの高度な薬剤耐性分離株を含む)に対し、in vitroにおいて良好な殺菌および殺菌活性を示した。これらの精油とその主要なフェノール成分は、犬外耳炎治療のに対し、in vivoでさらに調査される可能性を持っている。. ¿Sabías que el aceite de orégano está considerado como uno de los mejores remedios naturales para combatir la candidiasis? doi:10.1002/iub.1879, Zhang, H., Liu, H., Iles, K. E., Liu, R.-M., Postlethwait, E. M., Laperche, Y., et al. 79 (6), 1019–1031. 35 (25), 2949–2959. Tesis de Magíster en Producción Animal, línea de profundización en nutrición de monogástricos. Anti-proliferative Effects of Carvacrol on a Human Metastatic Breast Cancer Cell Line, MDA-MB 231. Colorectal cancer (Caco-2 cell line) also exhibited reduced cell viability and a significant increase of early apoptotic cells after carvacrol incubation (115 μM) (Llana-Ruiz-Cabello et al., 2014). ROS and the DNA Damage Response in Cancer. We extracted the following data from the included articles: author, year, country, data about the monoterpene (source, obtention method), concentration and/or dose, type of animal or cell line, results (cytotoxicity, cell proliferation, apoptosis, cell cycle, histology), proposed mechanisms involved in the antitumor effect and conclusion. Essential Oils of Aromatic Plant Species from the Atlantic Rainforest Exhibit Extensive Chemical Diversity and Antimicrobial Activity. 1996. Antioxidant, Antibacterial, and Cytotoxic Activities of the EthanolicOriganum vulgare Extract and its Major Constituents. Preliminary Study on the Mechanism of Carvacrol Regulating Hepatocellular Carcinoma Based on Network Pharmacology. 10, 175883591878645. doi:10.1177/1758835918786451, Pompella, A., De Tata, V., Paolicchi, A., and Zunino, F. (2006). 33 (4), e22275. J. Med. FIGURE 2. Estos aceites esenciales y sus principales componentes fenólicos tienen el potencial de ser investigados in vivo para el tratamiento de la otitis externa canina. In this context, carvacrol (5-isopropyl-2-methylphenol) and its thymol isomer (2-isopropyl-5-methylphenol), classified as natural multi-target compounds, deserve attention. [4] Propiedades. 62, 246–254. Differential Expression of Cell Cycle and Apoptosis Related Proteins in Colorectal Mucosa, Primary colon Tumours, and Liver Metastases. (2020). Carvacrol tiene un esqueleto de monoterpeno y es parte del grupo funcional fenoles. doi:10.1016/j.cld.2015.01.005. FOIA In this sense, anticancer therapies can follow two paths; using compounds that prevent the formation of ROS, and thereby preventing carcinogenesis; or using compounds that have as their action mechanism the increase of ROS, promoting oxidative stress within the tumor (de Sá Junior et al., 2017). Fitsiou, E., Anestopoulos, I., Chlichlia, K., Galanis, A., Kourkoutas, I., Panayiotidis, M. I., et al. Biomed. Inflammopharmacol 27 (6), 1275–1283. In vitro efficacy of oregano oil, thyme oil and their main phenolic constituents against bacterial and fungal isolates associated with canine otitis externa were investigated. Los límites de detección determinado LOD y límite de cuantificación LOQ fue de 0,0007 - 0,002 mg/L para el timol y 0,002 - 0,005 mg/L para el carvacrol, con una recuperación de 98,68 % y 90,95 %, respectivamente. In fact, cancer is a major global public health problem, and it is one of the four main causes of premature death (before 70 years old) in most countries, resulting in 8.8 million deaths per year (National Cancer Institute, 2019). (2018). Para el carvacrol, el límite de detección determinado LOD es 0,002 mg/L y el límite de cuantificación (LOQ) es 0,005 mg/L. Phytother Res. doi:10.1165/rcmb.2005-0280OC, Zhang, L., Yu, J., Park, B., Kinzler, K., and Vogelstein, B. The development of this method is essential to provide tools for decision making to identify regions where one or more ecotypes can potentially grow and produce high quality of essential oils contents of thymol and carvacrol. 2022 Sep 29;10(1):72-79. doi: 10.1080/23144599.2022.2123082. 44 (2), 177–189. 89 (6), 867–882. A PICOS strategy (patient or pathology, intervention, control, and other outcomes and type of study) was used based on: P: Animals with cancer or tumor cells; I: Treatment with carvacrol or thymol; C: No treatment, healthy cells or placebo (vehicle); O: Cytotoxic and antitumor effects, induction of apoptosis and inhibition of proliferation; S: Pre-clinical studies in vitro and in vivo. 670 (1), 85–91. The SYRCLE Risk of Bias tool was used to assess the risk of bias of all in vivo experimental studies (Hooijmans et al., 2014). Curr. Nat. Systemic Chemotherapy in Advanced Pancreatic Cancer. Available at: https://www.springer.com/gp/book/9781588297488 (Acesseced December 21, 2020). El carvacrol del aceite de orégano es un antioxidante con efecto anticancerígeno, sobre todo ante el cáncer de colon.En la Universidad Harbin (China) se estudia incluso su uso como agente terapéutico. Biol. Rev. Es un líquido incoloro, levemente soluble en agua y soluble en etanol y éter. Additionally, there was a marked phosphorylation of ERK1/2 and also inhibition of the PI3K/AKT signaling pathway, indicating that carvacrol regulates signaling pathways by inhibiting MAPK and PI3K (Lim et al., 2019). p53 and Apoptosis. 33 (7), 405–409. Eur. box-shadow: 0 0 0 2px #fff, 0 0 0 3px #2968C8, 0 0 0 5px rgba(65, 137, 230, 0.3); These factors limit the introduction of these compounds as a therapeutic option, and highlight the new for innovative studies to be undertaken. However, a phase I randomized clinical trial conducted in healthy subjects treated with carvacrol (1 or 2 mg/kg daily, p.o., during one month) revealed that this monoterpene did not lead to clinically significant changes, and did not cause any adverse effects, showing clinical safety and tolerability for this agent (Ghorani et al., 2021). Pathania, A. S., Guru, S. K., Verma, M. K., Sharma, C., Abdullah, S. T., Malik, F., et al. "; Int. Es un fenol monoterpenoide. (2020) also identified the cytotoxic effects of thymol on AGS cell viability, in addition to inducing apoptosis, by increasing ROS, Bax, Caspase-3, -9 levels and reducing Bcl-2 and GSH levels. doi:10.1007/s10787-019-00583-8, Chan, H., Ho, J., Liu, X., Zhang, L., Wong, S. H., Chan, M., et al. A oxidação com cloreto férrico, converte-o em dicarvacrol, enquanto que o pentacloreto de fósforo o transforma em clorocimol. (2019) demonstrated decreased cell viability in a concentration dependent manner and also marked apoptosis (mitochondrial pathway), accompanied by cleavage of PARP-1 and caspase-3 and an increased Bax protein level. University of Johannesburg, South Africa, Heidelberg University. (2005). D. R. Vásquez C. El orégano de monte (Lippia origanoides) del Alto Patía: Efecto del método de obtención de sus extractos sobre la composición y la actividad antioxidante de los mismos. Primal Fx Orégano Oil 91% Carvacrol Timol. Cancer Res. Creative Commons Attribution License (CC BY). They are matrix degradation enzymes (such as MMP), responsible for the degradation of the main constituents of basement membrane and extracellular matrix, facilitating the invasion of tumor cells and favoring the spread of cancer cells and metastases (Nagase et al., 2006; Shuman Moss et al., 2012; Jabłońska-Trypuć et al., 2016). Product Description Oil of Oregano has 36 mg carvacrol and thymol from an impressive 60-75% carvacrol oregano oil. Cold Spring Harbor Perspect. 2020, e8602879. Sobre Nosotros, Diferencia entre policarbonato y plexiglás. J. Biol. (2004). New Drug 14, 3–14. Plos Med. Liolios, O. Gortzi, S. Lalas, J. Tsaknis, I. Chinou; Liposomal incorporation of carvacrol and thymol isolated from the essential oil of Origanum dictamnus L. and in vitro antimicrobial activity. Detection limits (DL) and quantification limits (QL) were 0.0007 to 0.002 mg/L for, thymol and 0.002 to 0.005 mg/L for carvacrol with a recovery of 98.68% and 90.95% respectively. Carvacrol Suppresses Inflammatory Responses in Rheumatoid Arthritis Fibroblast‐like Synoviocytes. Assessment of in vivo studies risk of bias. doi:10.1016/j.ejphar.2015.12.046, Binétruy, B., Heasley, L., Bost, F., Caron, L., and Aouadi, M. (2007). This site needs JavaScript to work properly. 34 (3), 165–175. (2017). Science 290 (5493), 989–992. Med. Timol 1294 ---- 14,3 Carvacrol + Timol 1318 53,2 ---- J-Terpineno 1068 8,2 10,0 Orégano cimarrón Lippia origanoides LOH (hojas) Cultivo experimental CENIVAM p-Cimeno 1035 10,1 9,5 Timol 1298 35,8 34,0 p-Cimeno 1035 19,5 17,7 J-Terpineno 1068 9,7 6,8 Tomillo Thymus vulgaris TOM (hojas) Cultivo experimental CENIVAM Carvacrol 1315 4,3 5,7 Timol . University of Studies G. d'Annunzio Chieti and Pescara, Italy, Shenyang Pharmaceutical University, China. doi:10.4172/2167-0412.1000170, Hsu, S.-S., Lin, K.-L., Chou, C.-T., Chiang, A.-J., Liang, W.-Z., Chang, H.-T., et al. Según la FEN, "entre las sustancias activas presentes en los aceites esenciales del orégano se encuentran los compuestos fenólicos timol y carvacrol con actividad antimicrobiana". 2018, e9049252. doi:10.2478/intox-2014-0027, Melusova, M., Slamenova, D., Kozics, K., Jantova, S., and Horvathova, E. (2014). Elaboration of the manuscript: LS. (n = 20), Pseudomonas aeruginosa (n = 20; inklusive 10 Isolaten, die resistent zu einem oder zwei antimikrobiellen Wirkstoffen waren), Proteus mirabilis (n = 20) und Malassezia pachydermatis (n = 20) von Hunden mit einer Otitis externa verwendet. Biochem. 1), 177–183. Descripción general y diferencia clave 2. Ambos compuestos tienen la misma fórmula química; son isómeros estructurales. doi:10.1016/j.bcp.2005.10.005, Potočnjak, I., Gobin, I., and Domitrović, R. (2018). [9][10] 12, 133. doi:10.1007/s11655-020-3193-5, Martino, E., Casamassima, G., Castiglione, S., Cellupica, E., Pantalone, S., Papagni, F., et al. 1998. (2018). Cancer 110 (4), 908–915. and L.T.S.P.) También reduce la irritación en el tejido adiposo blanco. Comparison of Ultrastructural Changes and the Anticarcinogenic Effects of Thymol and Carvacrol on Ovarian Cancer Cells: Which Is More Effective?

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